Oxidant stress in healthy normal-weight, overweight, and obese individuals.
Abstract
This study was undertaken to investigate the association among BMI and lipid hydroperoxide (LH), total antioxidant status (TAS), superoxide dismutase (SOD), and reduced glutathione (GSH). Ninety (n = 90) healthy males and females (n = 23/67) (29 normal weight (BMI: 22.74 +/- 0.25 kg/m(2)), 36 overweight (BMI: 27.18 +/- 0.23 kg/m(2)), and 25 obese (33.78 +/- 0.48 kg/m(2))) participated in the study. Data collected included anthropometric measures, fasting blood glucose, lipid profile, LH, TAS, and enzymatic antioxidants (SOD, and reduced GSH). The results of the study showed that obese individuals had significantly increased LH levels compared to normal-weight individuals (obese vs. normal weight (0.88 +/- 0.05 vs. 0.67 +/- 0.03 micromol/l, P < 0.01)) but the increased levels were not significantly different when compared to the overweight group (obese vs. overweight (0.88 +/- 0.05 vs. 0.79 +/- 0.05 micromol/l)). No other consistent significant differences in TAS, SOD, and GSH were identified between groups. This study concluded that only obesity and not moderate overweight elevates LH levels. Furthermore, the levels of TAS, SOD, and GSH in obesity do not explain the increased LH levels observed in obesity.Citation
Brown, L.A., Kerr, C.J., Whiting, P., Finer, N., McEneny, J. and Ashton, T. (2009) 'Oxidant stress in healthy normal-weight, overweight, and obese individuals', Obesity, 17(3) pp.460-466.Journal
Obesity (Silver Spring, Md.)PubMed ID
19131942Additional Links
http://onlinelibrary.wiley.com/doi/10.1038/oby.2008.590/abstract;jsessionid=E42199CE0E33D3B29BA0331C65AC4115.f02t01Type
ArticleLanguage
enISSN
1930-7381ae974a485f413a2113503eed53cd6c53
10.1038/oby.2008.590
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