Recent Submissions

  • Guest editorial: Innovation in children’s social care: from conceptualisation to improved outcomes?

    Munro, Emily; Skouteris, Helen; Newlands, Fiona; Walker, Steve; University of Bedfordshire; Monash University; Children’s Services, Leeds City Council (Emerald Publishing Limited, 2021-09-14)
  • ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration

    Luo, Jixian; Zheng, Huiguang; Wang, Sen; Li, Dingyun; Ma, Wenli; Wang, Lan; Crabbe, M. James C. (Oxford University Press, 2021-09-11)
    The fusion gene of ABL1 is closely related to tumor proliferation, invasion, and migration. It has been reported recently that ABL1 itself is required for T-cell acute lymphoblastic leukemia (T-ALL) cell migration induced by CXCL12. Further experiments revealed that ABL1 inhibitor Nilotinib inhibited leukemia cell migration induced by CXCL12, indicating the possible application of Nilotinib in T-ALL leukemia treatment. However, the interacting proteins of ABL1 and the specific mechanisms of their involvement in this process need further investigation. In the present study, ABL1 interacting proteins were characterized and their roles in the process of leukemia cell migration induced by CXCL12 were investigated. Co-immunoprecipitation in combination with mass spectrometry analysis identified 333 proteins that interact with ABL1, including Cofilin1. Gene ontology analysis revealed that many of them were enriched in the intracellular organelle or cytoplasm, including nucleic acid binding components, transfectors, or co-transfectors. Kyoto Encyclopedia of Genes and Genomes analysis showed that the top three enriched pathways were translation, glycan biosynthesis, and metabolism, together with human diseases. ABL1 and Cofilin1 were in the same complex. Cofilin1 binds the SH3 domain of ABL1 directly; however, ABL1 is not required for the phosphorylation of Cofilin1. Molecular docking analysis shows that ABL1 interacts with Cofilin1 mainly through hydrogen bonds and ionic interaction between amino acid residues. The mobility of leukemic cells was significantly decreased by Cofilin1 siRNA. These results demonstrate that Cofilin1 is a novel ABL1 binding partner. Furthermore, Cofilin1 participates in the migration of leukemia cells induced by CXCL12. These data indicate that ABL1 and Cofilin1 are possible targets for T-ALL treatment.
  • Exercise-induced salivary hormone responses to high-intensity, self-paced running

    Leal, Diogo Luis Campos Vaz; Taylor, Lee; Hough, John (Human Kinetics, 2021-01-20)
    Physical overexertion can lead to detrimental overreaching states without sufficient recovery, which may be identifiable by blunted exercise-induced cortisol and testosterone responses. A running test (RPETP) elicits reproducible plasma cortisol and testosterone elevations (in a healthy state) and may detect blunted hormonal responses in overreached athletes. This current study determined the salivary cortisol and testosterone responses reproducibility to the RPETP, to provide greater practical validity using saliva compared with the previously utilized blood sampling. Second, the relationship between the salivary and plasma responses was assessed. A total of 23 active, healthy males completed the RPETP on 3 occasions. Saliva (N = 23) and plasma (N = 13) were collected preexercise, postexercise, and 30 minutes postexercise. Salivary cortisol did not elevate in any RPETP trial, and reduced concentrations occurred 30 minutes postexercise (P = .029, η2 = .287); trial differences were observed (P < .001, η2 = .463). The RPETP elevated (P < .001, η2 = .593) salivary testosterone with no effect of trial (P = .789, η2 = .022). Intraindividual variability was 25% in cortisol and 17% in testosterone. "Fair" intraclass coefficients of .46 (cortisol) and .40 (testosterone) were found. Salivary and plasma cortisol positively correlated (R = .581, P = .037) yet did not for testosterone (R = .345, P = .248). The reproducibility of salivary testosterone response to the RPETP is evident and supports its use as a potential tool, subject to further confirmatory work, to detect hormonal dysfunction during overreaching. Salivary cortisol responds inconsistently in a somewhat individualized manner to the RPETP.
  • Working from home during Covid-19: doing and managing technology-enabled social interaction with colleagues at a distance

    Lal, Banita; Dwivedi, Yogesh Kumar; Haag, Markus; ; University of Bradford; Swansea University; University of Bedfordshire (Springer, 2021-08-27)
    With the overnight growth in Working from Home (WFH) owing to the pandemic, organisations and their employees have had to adapt work-related processes and practices quickly with a huge reliance upon technology. Everyday activities such as social interactions with colleagues must therefore be reconsidered. Existing literature emphasises that social interactions, typically conducted in the traditional workplace, are a fundamental feature of social life and shape employees' experience of work. This experience is completely removed for many employees due to the pandemic and, presently, there is a lack of knowledge on how individuals maintain social interactions with colleagues via technology when working from home. Given that a lack of social interaction can lead to social isolation and other negative repercussions, this study aims to contribute to the existing body of literature on remote working by highlighting employees' experiences and practices around social interaction with colleagues. This study takes an interpretivist and qualitative approach utilising the diary-keeping technique to collect data from twenty-nine individuals who had started to work from home on a full-time basis as a result of the pandemic. The study explores how participants conduct social interactions using different technology platforms and how such interactions are embedded in their working lives. The findings highlight the difficulty in maintaining social interactions via technology such as the absence of cues and emotional intelligence, as well as highlighting numerous other factors such as job uncertainty, increased workloads and heavy usage of technology that affect their work lives. The study also highlights that despite the negative experiences relating to working from home, some participants are apprehensive about returning to work in the traditional office place where social interactions may actually be perceived as a distraction. The main contribution of our study is to highlight that a variety of perceptions and feelings of how work has changed via an increased use of digital media while working from home exists and that organisations need to be aware of these differences so that they can be managed in a contextualised manner, thus increasing both the efficiency and effectiveness of working from home.
  • Tracking human motion direction with commodity wireless networks

    Rahaman, Habibur; Dyo, Vladimir; University of Bedfordshire (IEEE, 2021-09-07)
    Detecting when a person leaves a room, or a house is essential to create a safe living environment for people suffering from dementia or other mental disorders. The approaches based on wearable devices, e.g. GPS bracelets may detect such events require periodic maintenance to recharge or replace batteries, and therefore may not be suitable for certain types of users. On the other hand, camera-based systems require illumination and raise potential privacy concerns. In this paper, we propose a device-free walking direction detection approach based on RF-sensing, which does not require a person to wear any equipment. The proposed approach monitors the signal strength fluctuations caused by the human body on ambient wireless links and analyses its spatial patterns using a convolutional neural network to identify the walking direction. The approach has been evaluated experimentally to achieve up to 98% classification accuracy depending on the environment.
  • Time series chlorophyll-A concentration data analysis: a novel forecasting model for aquaculture industry

    Eze, Elias Chinedum; Kirby, Sam; Attridge, John; Ajmal, Tahmina; University of Bedfordshire; Chelsea Technology Group (2021-06-29)
    Eutrophication in fresh water has become a critical challenge worldwide and chlorophyll-a content is a key water quality parameter that indicates the extent of eutrophication and algae concentration in a body of water. In this paper, a forecasting model for the high accuracy prediction of chlorophyll-a content is proposed to enable aquafarm managers to take remediation actions against the occurrence of toxic algal blooms in the aquaculture industry. The proposed model combines the ensemble empirical mode decomposition (EEMD) technique and a deep learning (DL) long short-term memory (LSTM) neural network (NN). With this hybrid approach, the time-series data are firstly decomposed with the aid of the EEMD algorithm into manifold intrinsic mode functions (IMFs). Secondly, a multi-attribute selection process is employed to select the group of IMFs with strong correlations with the measured real chlorophyll-a dataset and integrate them as inputs for the DL LSTM NN. The model is built on water quality sensor data collected from the Loch Duart salmon aquafarm in Scotland. The performance of the proposed novel hybrid predictive model is validated by comparing the results against the dataset. To measure the overall accuracy of the proposed novel hybrid predictive model, the Mean Absolute Error (MAE), Mean Square Error (MSE), Root Mean Square Error (RMSE), and Mean Absolute Percentage Error (MAPE) were used.
  • A decade on from the summer riots

    Bateman, Tim (2021-07-27)
  • Developing a novel water quality prediction model for a South African aquaculture farm

    Eze, Elias Chinedum; Halse, Sarah; Ajmal, Tahmina; University of Bedfordshire; Abagold Limited (MDPI, 2021-06-28)
    Providing an accurate prediction of water quality parameters for improved water quality management is a topical issue in the aquaculture industry. Conventional prediction methods have shown different challenges like a poor generalization, poor prediction accuracy, and high time complexity. Aiming at these challenges, a novel hybrid prediction model with ensemble empirical mode decomposition (EEMD) and deep learning (DL) long-short term memory (LSTM) neural network is proposed in this paper. In this innovative hybrid EEMD-DL-LSTM model, firstly, the integrity of the datasets is enhanced by applying moving average filtering and linear interpolation techniques of water quality parameter datasets pre-treatment. Secondly, the measured real sensor water quality parameters dataset is decomposed with the aid of the EEMD algorithm into disparate IMFs and a corresponding residual item. Thirdly, a multi-feature selection process is applied to make a careful selection of a strongly correlated group of IMFs with the measured real water quality parameter datasets and integrate them as inputs to the DL-LSTM neural network. The presented model is built on water quality sensor data collected from an Abalone farm in South Africa. The performance of the novel hybrid prediction model is validated by comparing the results against the real datasets. To measure the overall accuracy of the novel hybrid prediction model, different statistical indices, namely the Mean Absolute Error (MAE), Mean Square Error (MSE), Root Mean Square Error (RMSE), and Mean Absolute Percentage Error (MAPE), are used.
  • Youth Justice News [January 2021]

    Bateman, Tim (Sage, 2021-01-11)
  • Youth Justice News [April 2021]

    Bateman, Tim (Sage, 2021-04-25)
  • Biochemistry of buffering capacity and ingestion of buffers in exercise and athletic performance

    Saunders, Bryan; Artioli, Guilherme Giannini; Dolan, Eimear; Jones, Rebecca Louise; Matthews, Joseph; Sale, Craig (Routledge International Handbooks, 2021-01-22)
  • The prevalence of daily sedentary time in south Asian adults: a systematic review

    Dey, Kamalesh C.; Zakrzewski-Fruer, Julia K.; Smith, Lindsey Rachel; Jones, Rebecca Louise; Bailey, Daniel Paul (MDPI, 2021-09-01)
    This study aimed to systematically review total daily sedentary time in South Asian adults. Seven electronic databases were searched, identifying relevant articles published in peer-reviewed journals between March 1990 and March 2021. The study was designed in accordance with PRISMA guidelines. Prospective or cross-sectional design studies reporting total daily sedentary time in South Asian adults (aged ≥18 years), reported in English, were included. Study quality and risk of bias were assessed, and the weighted mean total daily sedentary time was calculated. Fourteen full texts were included in this systematic review from studies that were conducted in Bangladesh, India, Norway, Singapore, and the United Kingdom. Pooled sedentary time across all studies was 424 ± 8 min/day. Sedentary time was measured using self-report questionnaires in seven studies, with a weighted mean daily sedentary time of 416 ± 19 min/day. Eight studies used accelerometers and inclinometers with a weighted mean sedentary time of 527 ± 11 min/day. South Asian adults spend a large proportion of their time being sedentary, especially when recorded using objective measures (~9 h/day). These findings suggest that South Asians are an important target population for public health efforts to reduced sedentary time, and researchers and practitioners should seek to standardise and carefully consider the tools used when measuring sedentary time in this population.
  • Grieving a disrupted biography: an interpretative phenomenological analysis exploring barriers to the use of mindfulness after neurological injury or impairment

    Finlay, K. A.; Hearn, J.H.; Chater, Angel M.; University of Reading; Manchester Metropolitan University; University of Bedfordshire (Biomed Central, 2021-08-24)
    Mindfulness has demonstrated strong utility for enhancing self-management and health outcomes in chronic illness. However, sensation-focused mindfulness techniques may not be appropriate for clinical populations with neurological injury. This study aimed to identify how expert mindfulness teachers with sensory loss/impairment naturalistically adapt and experience mindfulness. We aimed to highlight the rationale for and barriers to mindfulness practice when living with sensory loss. A qualitative, semi-structured interview design was used, analysed via Interpretative Phenomenological Analysis (IPA). Eight (5 females, 3 males) mindfulness teachers with neurological injury were recruited via a national registry of Mindfulness for Health teachers. Interviews (range: 50-93 min) were completed, transcribed verbatim and analysed idiographically for descriptive, linguistic and conceptual themes, before a cross-case analysis was completed. Two superordinate themes were identified: (1) Overcoming a disrupted biography; and (2) Proactive self-management. These themes considered the challenge of reconciling, through grief, a past health status with the present reality of living with sensory loss due to Spinal Cord Injury, Multiple Sclerosis or Functional Neurological Disorder. Mindfulness was experienced as a method by which proactive choices could be made to maintain control and autonomy in health, reducing perceptions of suffering, psychological distress, cognitive reactivity and rumination. Mindfulness was found to support the self-management of health after neurological injury/impairment. Mindfulness meditation presented an initial challenge as trauma and grief processes were (re-)activated during mindfulness sessions. However, mindfulness was found to support the resolution of these grief processes and encourage adaptive approach-based coping and acceptance of health and neurological impairment/injury.
  • Effects of water injection strategies on oxy-fuel combustion characteristics of a dual-injection spark ignition engine

    Li, Xiang; Pei, Yiqiang; Li, Dayou; Ajmal, Tahmina; Rana, Khaqan-Jim; Aitouche, Abdel; Mobasheri, Raouf; Peng, Zhijun; University of Bedfordshire; Tianjin University; et al. (MDPI, 2021-08-26)
    Currently, global warming has been a serious issue, which is closely related to anthropogenic emission of Greenhouse Gas (GHG) in the atmosphere, particularly Carbon Dioxide (CO2). To help achieve carbon neutrality by decreasing CO2 emissions, Oxy-Fuel Combustion (OFC) technology is becoming a hot topic in recent years. However, few findings have been reported about the implementation of OFC in dual-injection Spark Ignition (SI) engines. This work numerically explores the effects of Water Injection (WI) strategies on OFC characteristics in a practical dual-injection engine, including GDI (only using GDI), P50-G50 (50% PFI and 50% GDI) and PFI (only using PFI). The findings will help build a conceptual and theoretical foundation for the implementation of OFC technology in dual-injection SI engines, as well as exploring a solution to increase engine efficiency. The results show that compared to Conventional Air Combustion (CAC), there is a significant increase in BSFC under OFC. Ignition delay (θF) is significantly prolonged, and the spark timing is obviously advanced. Combustion duration (θC) of PFI is a bit shorter than that of GDI and P50-G50. There is a small benefit to BSFC under a low water-fuel mass ratio (Rwf). However, with the further increase of Rwf from 0.2 to 0.9, there is an increment of 4.29%, 3.6% and 3.77% in BSFC for GDI, P50-G50 and PFI, respectively. As WI timing (tWI) postpones to around −30 °CA under the conditions of Rwf ≥ 0.8, BSFC has a sharp decrease of more than 6 g/kWh, and this decline is more evident under GDI injection strategy. The variation of maximum cylinder pressure (Pmax) and combustion phasing is less affected by WI temperature (TWI) compared to the effects of Rwf or tWI. BSFC just has a small decline with the increase of TWI from 298 K to 368 K regardless of the injection strategy. Consequently, appropriate WI strategies are beneficial to OFC combustion in a dual-injection SI engine, but the benefit in fuel economy is limited.
  • Oxy-fuel combustion for carbon capture and storage in internal combustion engines - a review

    Li, Xiang; Peng, Zhijun; Pei, Yiqiang; Ajmal, Tahmina; Rana, Khaqan-Jim; Aitouche, Abdel; Mobasheri, Raouf; ; University of Bedfordshire; Tianjin University; et al. (2021-08-18)
    As the impacts of global warming have become increasingly severe, oxy-fuel combustion has been widely considered a promising solution for carbon capture and storage (CCS) to reduce carbon dioxide (CO2) to achieve net-zero emissions. In the past few decades, researchers around the world have demonstrated improvements by the application of oxy-fuel combustion to internal combustion (IC) engines. This article presents a comprehensive review of the experimental and simulation studies about oxy-combustion for CCS in IC engines. To give a more comprehensive understanding, it has included a detailed explanation of the essential components contained in an oxy-fuel IC engine and its typical operating parameters. The oxy-fuel IC engine components include the system of oxygen supply, exhaust gas recirculation (EGR), water injection, fuel injection, and CCS. In order to optimise the combustion process, it is required to adopt the appropriate values for the oxygen concentration, EGR rate, ignition timing, compression ratio, fuel injection, and water injection in oxy-fuel engines. The detailed literature review and analysis presented provide a basis for the selection of oxy-fuel combustion for CCS as a prospective solution to reduce carbon emissions in IC engines.
  • An evolving model of best practice in a community physical activity programme: a case study of ‘Active Herts’

    Carr, Shelby; Burke, Amanda; Chater, Angel M.; Howlett, Neil; Jones, Andy (Human Kinetics, 2021-08-23)
    Background: Community-based physical activity programmes typically evolve to respond to local conditions and feedback from stakeholders. Process evaluations are essential for capturing how programmes are implemented, yet often fail to capture delivery evolution over time, meaning missed opportunities for capturing lessons learnt. Methods: This research paper reports on a staged approach to a process evaluation undertaken within a community-based UK 12-month physical activity programme that aimed to capture change and adaptation to programme implementation. Twenty-five one-to-one interviews, and twelve focus groups took place over the three years of programme delivery. Participants included programme participants, management, and service deliverers. Results: Programme adaptations that were captured through the ongoing process evaluation included changes to the design of promotional material, programme delivery content, ongoing training in behaviour change and the addition of regular participant community events. We address how these strands evolved over programme delivery, and how the process evaluation was able to capture them. Conclusion: The pragmatic evaluation approach enabled changes in response to the local context, as well as improvements in the programme to be captured in a timely manner, allowing the delivery to be responsive and the evaluation flexible.
  • A non-enzymatic glucose sensor via uniform copper nanosphere fabricated by two-step method

    Yu, Miaomiao; Weng, Zhankun; Hu, Jing; Zhu, Xiaona; Song, Hangze; Wang, Shenzhi; Cao, Siyuan; Song, Zhengxun; Xu, Hongmei; Li, Jinhua; et al. (Elsevier Ltd, 2021-08-10)
    Herein, we explored an effective way to obtain uniform copper nanoparticles by irradiating Cu2O microparticles in ethanol with a 1064 nm laser. The morphology, structure and chemical composition of as-prepared copper nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. It is interesting that the diameter of obtained spherical copper nanoparticles can be finely tuned by changing the irradiation time. Moreover, we also found that the particle size of copper nanoparticles can be reduced to ~63 nm when the irradiation time is 30 min. Inspired by the fast-developing non-enzymatic glucose sensors, the electrochemical activity of the copper nanoparticles toward glucose in alkaline media was further investigated. Notably, the electrochemical results reveal that the prepared copper nanoparticles possess a good prospect in non-enzymatic glucose sensor.
  • Factors that facilitate or hinder whole system integrated care for obesity and mental health: a scoping review protocol

    Liapi, Fani; Chater, Angel M.; Randhawa, Gurch; Pappas, Yannis; University of Bedfordshire (BMJ, 2021-08-10)
    Integrated care aims to improve population health. Obesity and mental health are major health issues worldwide. The complexity of the multifactorial drivers of these public health problems has led to the adoption of a whole system approach. This review aims to highlight factors that influence the planning, implementation and evaluation of whole system integrated care for these conditions. Using the framework of Arksey and O' Malley, we will perform a comprehensive search in the following databases: MEDLINE, CINAHL, PsychINFO, PubMed, British Nursing Database, Web of Science, Health Systems Evidence, Cochrane Library and University of York Centre for Reviews and Dissemination. Further hand-search of reference lists and the grey literature will be conducted. The search will be restricted to articles published from 2000 to 2020. The review is expected to be completed by August 2021. Full texts of the potential studies will be screened for the inclusion criteria. Quality of studies will be appraised. Narrative synthesis will be completed using data extracted from the included studies. A favourable ethics opinion for this study was obtained from the Institute for Health Research Ethics Committee of the University of Bedfordshire (IHREC937). This review expects to identify information relating to factors that facilitate or hinder whole system integrated care for obesity and mental health. The finding from this review will be widely disseminated to stakeholders to inform implementation of whole system integrated care initiatives.
  • Running performance and thermal sensation in the heat are improved with menthol mouth rinse but not ice slurry ingestion

    Dascombe BJ; Stevens, C.J.; Thoseby, B.; Sculley, D.V.; Callister, R.; Taylor, Lee; ; University of Newcastle, Australia; University of Bedfordshire (Blackwell Munksgaard, 2015-09-26)
    The purpose of this study was to compare the effects of a cooling strategy designed to predominately lower thermal state with a strategy designed to lower thermal sensation on endurance running performance and physiology in the heat. Eleven moderately trained male runners completed familiarization and three randomized, crossover 5-km running time trials on a non-motorized treadmill in hot conditions (33 °C). The trials included ice slurry ingestion before exercise (ICE), menthol mouth rinse during exercise (MEN), and no intervention (CON). Running performance was significantly improved with MEN (25.3 ± 3.5 min; P = 0.01), but not ICE (26.3 ± 3.2 min; P = 0.45) when compared with CON (26.0 ± 3.4 min). Rectal temperature was significantly decreased with ICE (by 0.3 ± 0.2 °C; P < 0.01), which persisted for 2 km of the run and MEN significantly decreased perceived thermal sensation (between 4 and 5 km) and ventilation (between 1 and 2 km) during the time trial. End-exercise blood prolactin concentration was elevated with MEN compared with CON (by 25.1 ± 24.4 ng/mL; P = 0.02). The data demonstrate that a change in the perception of thermal sensation during exercise from menthol mouth rinse was associated with improved endurance running performance in the heat. Ice slurry ingestion reduced core temperature but did not decrease thermal sensation during exercise or improve running performance.
  • Hsp72 and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation

    Gibson, Oliver R.; Tuttle, James A.; Watt, Peter W.; Maxwell, Neil S.; Taylor, Lee; ; Brunel University; University of Brighton; University of Bedfordshire; Qatar Orthopaedic and Sports Medicine Hospital; et al. (Springer, 2016-08-11)
    Increased intracellular heat shock protein-72 (Hsp72) and heat shock protein-90α (Hsp90α) have been implicated as important components of acquired thermotolerance, providing cytoprotection during stress. This experiment determined the physiological responses characterising increases in Hsp72 and Hsp90α mRNA on the first and tenth day of 90-min heat acclimation (in 40.2 °C, 41.0 % relative humidity (RH)) or equivalent normothermic training (in 20 °C, 29 % RH). Pearson’s product-moment correlation and stepwise multiple regression were performed to determine relationships between physiological [e.g. (Trec, sweat rate (SR) and heart rate (HR)] and training variables (exercise duration, exercise intensity, work done), and the leukocyte Hsp72 and Hsp90α mRNA responses via reverse transcription quantitative polymerase chain reaction (RT-QPCR) (n = 15). Significant (p < 0.05) correlations existed between increased Hsp72 and Hsp90α mRNA (r = 0.879). Increased core temperature was the most important criteria for gene transcription with ΔTrec (r = 0.714), SR (r = 0.709), Trecfinal45 (r = 0.682), area under the curve where Trec ≥ 38.5 °C (AUC38.5 °C; r = 0.678), peak Trec (r = 0.661), duration Trec ≥ 38.5 °C (r = 0.650) and ΔHR (r = 0.511) each demonstrating a significant (p < 0.05) correlation with the increase in Hsp72 mRNA. The Trec AUC38.5 °C (r = 0.729), ΔTrec (r = 0.691), peak Trec (r = 0.680), Trecfinal45 (r = 0.678), SR (r = 0.660), duration Trec ≥ 38.5 °C (r = 0.629), the rate of change in Trec (r = 0.600) and ΔHR (r = 0.531) were the strongest correlate with the increase in Hsp90α mRNA. Multiple regression improved the model for Hsp90α mRNA only, when Trec AUC38.5 °C and SR were combined. Training variables showed insignificant (p > 0.05) weak (r < 0.300) relationships with Hsp72 and Hsp90α mRNA. Hsp72 and Hsp90α mRNA correlates were comparable on the first and tenth day. When transcription of the related Hsp72 and Hsp90α mRNA is important, protocols should rapidly induce large, prolonged changes in core temperature.

View more