• Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

      Yánez, Diana C.; Lau, Ching-In; Chawda, Mira Manilal; Ross, Susan; Furmanski, Anna L.; Crompton, Tessa; University College London; University of Bedfordshire; Universidad San Francisco de Quito (Journal of Allergy and Clinical Immunology, 2019-07-24)
      Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.