• Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

      Law, Ah-Lai; Jalal, Shamsinar; Pallett, Tommy; Mosis, Fuad; Guni, Ahmad; Brayford, Simon; Yolland, Lawrence; Marcotti, Stefania; Levitt, James A.; Poland, Simon P.; et al. (Nature Research, 2021-09-28)
      Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. Here we identify Nance-Horan Syndrome-like 1 protein (NHSL1) as a direct binding partner of the Scar/WAVE complex, which co-localise at protruding lamellipodia. This interaction is mediated by the Abi SH3 domain and two binding sites in NHSL1. Furthermore, active Rac binds to NHSL1 at two regions that mediate leading edge targeting of NHSL1. Surprisingly, NHSL1 inhibits cell migration through its interaction with the Scar/WAVE complex. Mechanistically, NHSL1 may reduce cell migration efficiency by impeding Arp2/3 activity, as measured in cells using a Arp2/3 FRET-FLIM biosensor, resulting in reduced F-actin density of lamellipodia, and consequently impairing the stability of lamellipodia protrusions.
    • Nano-ferrite near-field microwave imaging for in-body applications

      Abbasi, Qammer Hussain; Ren, Aifeng; Qing, Maojie; Zhao, Nan; Wang, Mingming; Gao, Ge; Yang, Xiaodong; Zhang, Zhiya; Hu, Fangming; Ur-Rehman, Masood; et al. (Institute of Electrical and Electronics Engineers, 2018-06-04)
      In recent years, nanotechnology has become indispensable in our lives, especially in the medical field. The key to nanotechnology is the perfect combination of molecular imaging and nanoscale probes. In this paper, we used iron oxide nanoparticles as a nanoprobe because it is widely used in clinical MRI and other molecular imaging techniques. We built our own experimental environment and used absorbing materials during the whole experiment to avoid electromagnetic interference with the surroundings. Moreover, we repeated the experiment many times to exclude the influence of contingency. Hence, the experimental data we obtained were relatively precise and persuasive. Finally, the results demonstrated that the iron oxide nanoparticles were appropriate for use as contrast agents in biological imaging.
    • Nanoantenna arrays combining enhancement and beam control for fluorescence-based sensing applications

      Dorh, N.; Sarua, A; Ajmal, Tahmina; Okache, Julius; Rega, C.; Müller, G.; Cryan, M.; University of Bristol; University of Bedfordshire; ABB Ltd; et al. (OSA - The Optical Society, 2017-12-31)
      This paper presents measured fluorescence enhancement results for ~250 × 250 element aluminum nanoantenna arrays fabricated using electron beam lithography. The arrays have been designed to use diffractive coupling to enhance and control the direction of fluorescent emission. Highly directional emission is obtained at the designed angles with beam widths simulated to be in the range of 4–6°. Angle-resolved spectroscopy measurements of dye-coated nanoantenna arrays were in good agreement with finite difference time domain modeling. Critically, these results were obtained for near UV wavelengths (~360 nm), which is relevant to a number of biosensing applications.
    • A narrative review of the theoretical foundations of loneliness

      Tzouvara, Vasiliki; Papadopoulos, Chris; Randhawa, Gurch; University of Bedfordshire (Mark Allen Group, 2015-07-01)
      Loneliness has been found to relate to a wide range of harmful health outcomes. The adverse effects of loneliness upon people’s lives emphasise the importance of understanding its nature and process. A number of theoretical and conceptual foundations have been proposed by scholars and are discussed and reflected upon in this article. The discussion and understanding of loneliness theoretical foundations provide useful insights toward the interpretation of its occurrence.
    • The nasty woman and the neo femme fatale in contemporary cinema

      Piotrowska, Agnieszka (Routledge, 2018-11-20)
      The Nasty Woman and the Neo Femme Fatale in Contemporary Cinema puts forward the theoretical notion of the ‘nasty woman’ as a means of examining female protagonists in contemporary culture and cinema, particularly films directed by women. The phrase is taken from an insult thrown at Hillary Clinton during the 2016 Presidential election debates and reclaimed by the feminists worldwide. The volume also draws from the figure of the femme fatale in film noir. Piotrowska presents ‘the nasty woman’ across cultural and mythical landscape as a figure fighting against the entitlement of the patriarchy. The writer argues that in films such as Zero Dark Thirty, Red Road, Stories We Tell, and even Gone Girl the ‘nastiness’ of female characters creates a new space for reflection on contemporary society and its struggles against patriarchal systems. The nasty woman or neo femme fatale is a figure who disrupts stable situations and norms; she is pro-active and self-determining, and at times unafraid to use dubious means to achieve her goals. She is often single, but when married she subverts and undermines the fundamental principles of this patriarchal institution. For students and researchers in Cultural Studies, Women’s, Gender and Sexuality Studies, Film Studies and Psychoanalysis in Film Studies, The Nasty Woman and the Neo Femme Fatale in Contemporary Cinema offers an original way of thinking about female creativity and subjectivity. It is also a proud celebration of feminist and female authorship in contemporary Hollywood.
    • Nation branding for foreign direct investment: a review and directions for research and strategy

      Papadopoulos, Nicolas; Hamzaoui-Essoussi, Leila; El Banna, Alia; Carleton University, Ottawa; University of Ottawa; University of Bedfordshire (Emerald, 2016-12-01)
      Purpose This study aims to address a heretofore neglected area in research, nation branding, for the purpose of attracting foreign direct investment (FDI). It compares and contrasts the well-established literature on decision-making and location choice in FDI with studies in the nascent field of nation branding, with a view to developing directions for future research that result from the identification of research gaps at the intersection point between the two areas. - Design/methodology/approach The study is based on a systematic and integrative review of several streams within the relevant literatures, from the theory of decision-making in FDI to the similarities and differences between advertising, promotion, branding and marketing for investment on the part of nations and sub- or supra-national places. - Findings Each of the two areas is characterized by lack of consensus as to the principal factors that affect investor and nation decisions and actions, resulting in several knowledge gaps that need to be addressed by new research along the lines suggested in the study. - Research limitations/implications A large number of avenues for potential future research are identified, from assessing the importance of target country image in location choice to the adverse effects arising from the emphasis on “promotion” rather than “marketing” on the part of places engaged in nation branding efforts. - Practical implications The study examines several problems that affect the practice of nation branding for FDI and points to alternative approaches that may enhance place marketers’ effectiveness in their efforts to attract foreign capital. - Originality/value Notwithstanding the global growth of FDI in volume and importance, and the omnipresence of nation branding campaigns to promote exports or attract tourism and investment, there has been virtually no research to date on the core issue, nation branding for FDI. The study uses a strategic perspective that highlights key nation branding issues related to FDI, and FDI issues related to nation branding, and suggests a comprehensive agenda for research in the future.
    • National Radio Archive feasibility study: a report prepared on behalf of the British library

      Hallett, Lawrie; Goddard, Grant; Nathan, Daniel; The British Library (The British Library, 2014-05-09)
      This Report examines the feasibility of creating a permanent, comprehensive archive of all future UK licensed radio broadcasting output.
    • National survey of commissioners' and service planners' views of public health nursing in the UK

      Davies, Nigel; Donovan, Helen; University of Bedfordshire; Royal College of Nursing (Elsevier B.V., 2016-10-27)
      Improving public health is a key policy area both in the United Kingdom (UK) and internationally. The governments across the four UK countries each have specific strategies to guide improvements in public health services, promote greater emphasis on how people can best be helped to live healthier lives and to help address the unprecedented challenges of both an increasing population and financial austerity. Nurses are often ideally suited and uniquely placed to respond to public health challenges as they understand the particular risks of individuals but also know the population and the communities they work in. Traditionally in the UK public health nurses have been seen as those in specialist community roles such as health visitors, school nurses and occupational health nurses and in some cases specialist practitioners. However, there is an increasing need for all nurses to embrace the contribution they can have to make every contact count. During 2015 the Royal College of Nursing in the UK (RCN) undertook a programme of work building on a previous project2 to showcase public health nursing (see www.nurses4PH.org.uk). As part of this wider RCN programme, a survey was conducted to explore the views of commissioners and others involved in designing and planning public health services about the nursing and midwifery contribution to public health. The aims were to explore the perceived value of nursing in public health, to better understand the roles of nurses and midwives in public health, how these roles were valued, and what and where the gaps were in public health nursing knowledge and education.
    • Navigating health literacy using interactive data visualisation

      Liu, Enjie; Zhao, Youbing; Wei, Hui; Roumeliotis, Stefanos; Kaldoudi, Eleni; University of Bedfordshire; University of Thrace (Institute of Electrical and Electronics Engineers Inc., 2016-12-19)
      It is commonly concluded that health literacy focuses on individual skills to obtain, process and understand health information and services necessary to make appropriate health decisions. To achieve this, an individual first needs to obtain an adequate level of health literacy. However, nowadays, the information that individuals encounter with regards to their health, the amount, credibility and quality of the data make it difficult for one to make judgments on their health and disease progression, let alone make informed decisions on behaviour change. In this paper, we will report our work in providing patients with efficient ways to explore and understand the relevant health literacy. We focus on two data types: 1) harvested medical evidence from PubMed on cardiorenal disease and its comorbidities, 2) data collected from patients including from PHR and wearable sensors. Our work provides ways for patients to visualise this data meaningfully. Our work aims to improve the health literacy for the general public and increase the population's understanding of the medical field, thus helping users to make informed decision with regards to their care.
    • (Near)ubiquitous connectivity is seductive

      Knight, Julia; Weedon, Alexis; University of Sunderland; University of Bedfordshire (SAGE PUBLICATIONS INC, 2012-10-29)
      Editorial
    • The need for EAP teacher knowledge in assessment

      Schmitt, Diane; Hamp-Lyons, Liz; Nottingham Trent University; University of Bedfordshire (Elsevier Ltd, 2015-05-08)
    • The need to improve fertility awareness

      Harper, Joyce; Boivin, Jacky; O'Neill, Helen C.; Brian, Kate; Dhingra, Jennifer; Dugdale, Grace; Edwards, Genevieve; Emmerson, Lucy; Grace, Bola; Hadley, Alison; et al. (Elsevier, 2017-04-08)
      Women and men globally are delaying the birth of their first child. In the UK, the average age of first conception in women is 29 years. Women experience age-related fertility decline so it is important that men and women are well-informed about this, and other aspects of fertility. A group of UK stakeholders have established the Fertility Education Initiative to develop tools and information for children, adults, teachers, parents and healthcare professionals dedicated to improving knowledge of fertility and reproductive health.
    • Negative psychological experiences and saliva secretory immunoglobulin A in field hockey players

      Taylor, Ian M.; Turner, James E.; Gleeson, Michael; Hough, John (Taylor and Francis Inc., 2014-11-11)
      Understanding psychological factors that affect immunity in sport might help to reduce infection risk in athletes. The present study examined within-person changes and individual differences in perceived coach control, intentions to drop out, and saliva secretory immunoglobulin A (SIgA). Thirty-two field hockey players completed questionnaires and provided saliva samples over a 2-month period. Within-person increases in individuals’ perceptions of psychological control and intentions to drop out were positively associated with SIgA concentration. Individual differences in control or drop-out intentions were not associated with SIgA. Interventions in athletes to prevent immune disturbances and reduce infection should consider these psychological factors.
    • Negative regulation of autophagy in activating nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 inflammasomes in the hippocampus of an epilepsy rat model

      Wu, Jia-Mei; Chen, Liqiang; Wang, Shuo; Li, Yingyu; Liu, Lei; Chen, Guang; Wang, Shu-Qiu; Zhou, Shaobo (American Scientific Publishers, 2019-06-25)
      Epilepsy, characterized by unpredictable and periodic seizures, is associated with chronic hippocampal inflammation and autophagy. Moreover, a molecular relationship between autophagy and inflammation in neurodegenerative disorders has been reported, highlighting the role of autophagy in the regulation of inflammation. To the best of our knowledge, there is no previous evidence of an association between nucleotide-binding oligomerization domain-like receptor family pyrin domaincontaining 3 (NLRP3) inflammasome and autophagy in epilepsy. Hence, we in this study aimed at investigating the possible association between NLRP3 inflammasome activation and autophagy in the development of epilepsy. A rat model of temporal lobe epilepsy was induced with lithiumpilocarpine. Five groups, i.e., control (n=20), status epilepticus (SE, n=30), SE+control (siRNA; n=15), SE+NLRP3 siRNA (n=30), and SE+wortmannin (n=30), were investigated. Real-time quantitative reverse transcription polymerase chain reaction, Western blotting, and quantum dotbased immunohistochemistry were used to detect the mRNA/protein expression levels of NLRP3, caspase-1, interleukin (IL)-1, IL-18, Beclin-1, and microtubule-associated protein light chain 3 (LC3) in the hippocampus. In addition, transmission electron microscopy was utilized to investigate autophagosome in the hippocampus of SE rats. We found that mRNA and protein expressions of NLRP3, caspase-1, IL-1, IL-18, LC3, and Beclin-1 were activated in the hippocampus. Gene silencing of NLRP3 suppressed caspase-1, IL-1, and IL-18 release and significantly ameliorated hippocampal damage. Furthermore, the LC3 and Beclin-1 expression levels decreased significantly after treatment with wortmannin. Importantly, NLRP3 inflammasome activation and IL-1/IL-18 releases were significantly enhanced after treatment with wortmannin, which implied a negative association between autophagy inhibition and NLRP3 inflammasome activation. Our study provides the first evidence that autophagy plays an important role in NLRP3 inflammasome activation in the development of epilepsy. These findings suggest that regulation of autophagy may be a promising potential strategy for treating patients with epilepsy.
    • Negotiating difference and belonging in families from mixed racial, ethnic and faith backgrounds in Britain: Implications for mental health

      Puthussery, Shuby; Caballero, Chamion; Edwards, Rosalind (Oxford University Press, 2008-09-30)
      Poster presentations: abstracts Key points * Mixed-parent couples in Britain were often in sustained relationships, and a high proportion were middle class. * The couples interviewed used three typical approaches to instil a sense of belonging in their children; particular approaches were not associated with particular racial or faith combinations: o Individual: children's sense of belonging was not seen as rooted in their mixed background. o Mix: children's mixed background was understood as a factual part of their identity; all aspects were emphasised. o Single: one aspect of children's mixed background was stressed. * Couples whose approach differed in giving their children a sense of belonging were not necessarily in conflict. For some, divergent approaches were complementary. Others saw difficulties between them as humanistic, political or personality choices. * Parents identified supportive or constraining resources and relationships in creating a sense of belonging, including neighbourhoods, schools, travel, languages, grandparents and children themselves. What some regarded as supportive, others saw as drawbacks. * Mixed-parent couples can be more concerned with other issues, such as children's safety and health, unity over discipline and financial security. * The researchers conclude that it is important that family support, health, education and social services do not make assumptions about mixed families. Families who seem to share a form of mixing can differ from each other. 'Mixedness' may be insignificant for some, compared to other issues. Mixed families would benefit from policies and practice that further tackle prejudice based on race and faith.
    • Negotiating freedoms in the convergent mediascape [editorial]

      Knight, Julia; Weedon, Alexis; University of Bedfordshire; University of Sunderland (SAGE, 2015-05-31)
    • Negotiating recreational access under asymmetrical power relations: the case of inland waterways in England

      Church, Andrew; Gilchrist, Paul; Ravenscroft, Neil (Routledge, 2007-03-01)
      This article addresses recreational conflict between anglers and boaters in England. While recognizing that interpersonal conflicts between individual anglers and boaters exist much as they do in other countries, the article argues that the position in England is mediated through complex land and property rights that position the stakeholders asymmetrically, as legal rights holders (anglers) and moral rights claimants (boaters). Under this scenario, negotiated attempts to increase access for boaters are interpreted not primarily as a means of addressing the asymmetry, but as a mechanism for underwriting the dominant property power of the anglers. Using data collected from focus groups involving stakeholders, the article suggests that in cases where recreational access to natural resources is mediated through sociopolitical institutions such as law, weaker stakeholders have very limited options in terms of the legal or social mechanisms through which he can pursue or assert their claims.
    • The negotiation of significance in dance performance: a model for human interaction in the context of difference

      Carr, Jane (Boomsbury, 2020-11-29)
      This chapter explores how dance may be appreciated in a contemporary context in which it can no longer be assumed that performers and audience make sense of dancing with reference to a shared culture. Writing from my position as a former dancer and now dance academic, I draw upon my experiences of dancing, researching and teaching dance with the aim of proposing some avenues ripe for philosophical investigation. Emphasizing that dancing is a communicative phenomenon, I argue that the philosophy of Maurice Merleau-Ponty provides welcome recognition of the human capacity for intersubjective, embodied experience which is of key importance to engagement with dancing as meaningful. I propose how the significance of dance performance might be understood through a process of negotiation grounded in intercorporeal experience. However, I recognize the challenge of difference – in relation to gender, sexualities, and/or cultures and abilities - to the self-other relationships which sustain such negotiations. Finally, I situate these reflections within the broader field of philosophical aesthetics to consider the potential of such encounters to contribute to aesthetic values attributed to dance.
    • The neoconservative party, or conservatism without tradition?

      Hoctor, Tom (Wiley, 2021-07-15)
      This article argues that the Conservative Party finds itself in a period of ideological crisis. The last significant period of intellectual realignment in the party led to the dominance of Hayekian market theory as a structuring logic for government. Under Boris Johnson, this economic logic is challenged by the political logic of neoconservatism, which restores the political through appeals to authority, hierarchy and quite particular articulations of the nature of the (national) community. To demonstrate this tension, the article examines how Brexit and the ‘levelling-up’ agenda can be understood as structured by this division between the economic and the political. Both of these logics are incompatible with older, traditional forms of conservatism and whichever is ultimately successful, this signals a major shift in the character of British conservatism and potentially ushers in a new era of conservatism without tradition.