A diverse and intricate signalling network regulates stem cell fate in the shoot apical meristem
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Authors
Dodsworth, StevenAffiliation
University of CambridgeIssue Date
2009-09-25
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At the shoot apex of plants is a small region known as the shoot apical meristem (SAM) that maintains a population of undifferentiated (stem) cells whilst providing cells for developing lateral organs and the stem. All aerial structures of the plant develop from the SAM post-embryogenesis, enabling plants to grow in a characteristic modular fashion with great phenotypic and developmental plasticity throughout their lifetime. The maintenance of the stem cell population is intimately balanced with cell recruitment into differentiating tissues through intercellular communication involving a complex signalling network. Recent studies have shown that diverse regulators function in SAM maintenance, many of which converge on the WUSCHEL (WUS) gene. In this review the diverse regulatory modules that function in SAM maintenance are discussed: transcriptional and epigenetic control, hormonal regulation, and the balance with organogenesis. The central role of WUS as an integrator of multiple signals is highlighted; in addition, accessory feedback loops emerge as a feature enabling dynamic regulation of the stem cell niche.Citation
Dodsworth S. (2009) 'A diverse and intricate signalling network regulates stem cell fate in the shoot apical meristem', Developmental Biology, 336 (1), pp.1-9.Publisher
Academic Press Inc.Journal
Developmental BiologyPubMed ID
19782675Additional Links
https://www.sciencedirect.com/science/article/pii/S0012160609012160Type
ArticleLanguage
enISSN
0012-1606ae974a485f413a2113503eed53cd6c53
10.1016/j.ydbio.2009.09.031
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