Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
Authors
Lau, Ching-InOutram, Susan V.
Saldaña, José Ignacio
Furmanski, Anna L.
Dessens, Johannes T.
Crompton, Tessa
Issue Date
2012-05-17
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Show full item recordAbstract
The function of Hedgehog signaling in hematopoiesis is controversial, with different experimental systems giving opposing results. Here we examined the role of Desert Hedgehog (Dhh) in the regulation of murine erythropoiesis. Dhh is one of 3 mammalian Hedgehog family proteins. Dhh is essential for testis development and Schwann cell function. We show, by analysis of Dhh-deficient mice, that Dhh negatively regulates multiple stages of erythrocyte differentiation. In Dhh-deficient bone marrow, the common myeloid progenitor (CMP) population was increased, but differentiation from CMP to granulocyte/macrophage progenitor was decreased, and the mature granulocyte population was decreased, compared with wild-type (WT). In contrast, differentiation from CMP to megakaryocyte/erythrocyte progenitor was increased, and the megakaryocyte/erythrocyte progenitor population was increased. In addition, we found that erythroblast populations were Dhh-responsive in vitro and ex vivo and that Dhh negatively regulated erythroblast differentiation. In Dhh-deficient spleen and bone marrow, BFU-Es and erythroblast populations were increased compared with WT. During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with WT.Citation
Lau C, Outram SV, Saldaña JI, Furmanski AL, Dessens JT, Crompton T (2012) 'Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog', Blood, 119 (20), pp.4741-4751.Publisher
American Society of HematologyJournal
BloodPubMed ID
22461491PubMed Central ID
PMC3375146Additional Links
http://www.bloodjournal.org/content/119/20/4741Type
ArticleLanguage
enISSN
0006-4971ae974a485f413a2113503eed53cd6c53
10.1182/blood-2011-10-387266
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